Ameliorating Role of Lactoferrin Against Letrozole Induced Toxicity on Liver of Female Rats

Document Type : Original Article

Authors

Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt

Abstract

Background: Drug-induced liver damage is a rare but significant form of liver disease caused by various medications. Discontinuing the offending medication is usually the treatment. The present study aimed to investigate the effectiveness of Lactoferrin as an antiinflammatory protein in letrozole induced liver toxicity. Methods: 28 female Wistar albino rats, weighing 200 ± 20 g, were randomly categorized into 4 groups including: Group A: control group (0.4 ml of saline /rat/day), Group B: letrozole group (1 mg.kg.d, for 30 days), Group C: Lactoferrin group (300 mg of LF/kg.d, for 30 days).  Group D: Letrozole plus Lactoferrin group; They were given letrozole a long with lactoferrin in the same previous doses. After 24 hours from the last dose, rats were sacrificed by cervical dislocation, their abdominal cavities were opened, liver was dissected, and histopathological changes were examined. Results:letrozole modelling resulted in a significant rise in body weight. Also, it induced hepatic steatosis and lipid accumulation in the liver. Lactoferrin treatment decreased liver congestion and hepatocellular damage. Conclusion: Lactoferrin had therapeutic effects on liver of rats treated by letrozole due to its anti inflamatory activities.

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Mansoura Journal of Biology
Volume 72, Issue 1
March 2025
Pages 20-26

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