Pinealectomy in Ehrlich ascites-inoculated mice increased the risk of liver and kidney injury

Document Type : Original Article

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Zoology Department, Faculty of Science, Mansoura University, Egypt

Abstract

Background: Pineal gland impairment, characterized by disrupted melatonin synthesis, which collectively impairs liver and kidney homeostasis. This study explored the role of pineal impairment (Pnx) in mice inoculated with Ehrlich ascites cells in increasing susceptibility to liver and kidney toxicity.
Methods and results: Female Swiss albino mice were divided into three groups (of five animals each) that were engrafted with Ehrlich tumor (ET) cells; one served as a control, one as a sham, and the last as a Pnx group. Alanine aminotransferase, aspartate aminotransferase, and alkaline phosphatase activities were significantly elevated, whereas total protein and albumin levels were markedly decreased in Pnx mice. In addition to the elevation of creatinine, urea, and uric acid levels, which were also seen in the Pnx group. Antioxidants SOD, CAT, GSH, GPx were significantly decreased, and an increase in GST in liver and kidney tissues with a marked increase in oxidative stress marker MDA. Histopathological investigations reflected changes in liver and kidney architecture with vascular congestion, apoptosis, and atrophy in Pnx mice.
Conclusions: Taken together, our findings indicated that depleting melatonin in Ehrlich ascites-inoculated mice increased the risk of hepatotoxicity and kidney toxicity

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Mansoura Journal of Biology
Volume 72, Issue 2
June 2025
Pages 68-77

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