Therapeutic impact of Extra Virgin Olive Oil on Bone Health in Ovariectomized-induced osteoporosis in rats

Document Type : Original Article

Authors

1 Zoology department-Faculty of Science-Mansoura University

2 Department of Surgery, Anesthesiology and Radiology -Faculty of Veterinary Medicine-Mansoura University

10.21608/mjb.2023.449567

Abstract

Osteoporosis is a global health problem that commonly occurs in elderly people, especially postmenopausal women. Unfortunately, the current strategies for osteoporosis treatment are frequently hampered by severe side effects, especially after long-term use. Therefore, this study is aimed to evaluate the potentially effective impact of extra virgin olive oil on postmenopausal osteoporosis treatment based on an ovariectomized (OVX) rat model. In this study, 24 female Wistar rats were used; the rats were divided into four equal groups: control group, rats given olive oil, OVX-group, and OVX rats given olive oil. At the end of the experimental period, bone mineral density (BMD) was measured by DEXA scan. Additionally, serum and bone level of different parameters were assessed. Our results revealed that olive-oil administration had a beneficial therapeutic effect in osteoporosis treatment, and there was a significant amelioration in different estimated parameters. This was demonstrated by preventing the changes in both bone remodeling and BMD. In addition to improving the hormonal changes, oxidant/antioxidant imbalance, and inflammatory cytokines abnormal levels associated with OVX-induced osteoporosis, Further, olive oil treatment showed a marked improvement in the histological architecture, including improvement of the cancellous and cortical bone appearance with less widened bone marrow spaces, and the endosteal surface appeared smooth and lined with osteoblast cells. It is concluded that olive oil utilization is efficacious in reducing the impact of ovariectomy-induced osteoporosis in rats. Additionally, it has the potential to serve as a viable remedy for postmenopausal osteoporosis, devoid of any detrimental side effects. 

Keywords

Mansoura Journal of Biology
Volume 65, Issue 4
December 2023
Pages 42-55

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