Protective effects of Momordica charantia extract against diabetes induced cardiac disorder in neonatal rats

Document Type : Original Article

Authors

Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt

10.21608/mjb.2023.449584

Abstract

: Diabetes mellitus (DM) is one of the risk factors in the development of vascular complications. Mormodica charantia (MC) was proven to be useful in improving DM and its complications. The present study aimed to investigate the effects of MC fruit aqueous extract on cardiac histopathological changes in neonates from diabetic mothers. Neonatal rats were divided into 4 groups; group (1): neonates from non-diabetic rats considered as a control group, group (2): neonates from non-diabetic rats supplemented with 250 mg/kg. b.wt of MC fruit aqueous extract, group (3): neonates from diabetic rats without treatment, and group (4): neonates from diabetic rats supplemented with 250 mg/kg of MC fruit aqueous extract. At the end of treatment after birth, the animals were sacrificed and the heart was removed and processed for histopathological study. In the present study, neonates from diabetic mothers showed altered heart tissue biomarkers (Cardiac troponin T (cTnT), Creatine kinase (CK-MB), and Lactate dehydrogenase (LDH)).  Also, an increase in Malondialdehyde (MDA) was observed in the heart tissues of the neonates of the diabetic mothers, While the level glutathione (GSH) was decreased in the heart tissue. Histopathological results showed the presence of focal cardiac fibrosis and increased cell proliferation in neonates from diabetic mothers.  In conclusion, MC has a promising ameliorative effect on the cardiac dysfunction in neonate rats and the management of cardiovascular alteration associated with maternal DM.

Keywords

Mansoura Journal of Biology
Volume 66, Issue 5
December 2023
Pages 39-46

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