Tocilizumab's Potential Therapeutic Effect in the therapy of Endometriosis

Document Type : Original Article

Authors

1 Facultyof science, Mansoura Unversity

2 Prof. of Obsterics & Gynecology, Faculty of Medicine, Mansoura Unıversıty

3 A. Prof. of Obsterics & Gynecology, Faculty of Medicine, Mansoura University

4 Prof. of Experimental Embryology, Facultyof science, Mansoura University

Abstract

Introduction: Endometriosis is a chronic inflammatory syndrome that typically affects premenopausal women and is characterized by the growth of endometrial tissue and stromal cellbeyond the uterus.Many pro-inflammatory cytokines, particularly tumor necrosis factor alpha (TNF-α), interleukin (IL)-6, IL8 and monocyte chemotactic protein-1 (MCP-1) play important roles in endometriosis pathogenesis.
Materials/ Methods:Endometriosis was studied using 18 of female Sprague rats. Animals were randomly separated into two sets: tocilizumab-treated animals and saline-treated animals.After endometrial tissues volumes were measured, immunohistochemical examination was evaluated.
Results:The treated and control groups had similar pretreatment spherical volumes (P>.05). There was a significant change between pretreatment and posttreatment implant volumes after treatment (P<.05).). Also immunohistochemistry technique show differences in immunoreaction intensity for IL6 in control and treated Group.

Keywords

Mansoura Journal of Biology
Volume 54, Issue 1
March 2022
Pages 1-5

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