The Suppressive Role of Proanthocyanidins Against Experimentally Induced Hepatic Fibrosis in Male Rats.

Document Type : Original Article

Authors

1 Professor of physiology, Zoology Department-Faculty of Science-Mansoura university

2 Professor of physiology ,Zoology Department-Faculty of Science-Mansoura university

3 PhD researcher Zoology Department-Faculty of Science-Mansoura university

Abstract

The protective effects of proanthocyanidins (PAs) have been investigated against hepatic fibrosis progression prompted by carbon tetrachloride (CCl4) in male rats. The experimental design was divided into two periods of four and eight weeks. The experimental rats of each period were divided into five groups. The rats of the first groups in two periods were served as controls did not receive any treatments. Second group received only olive oil at a dose (2 mL/kg bw), orally. Third group of rats were orally administered PAs (500mg/kg bw) daily. Fourth group of rats were orally administered CCl4 dissolved in olive oil (V/V) at a dose of (2 ml/kg bw) day after day. Fifth groups were orally administered PAs for one week alone, then concomitant with CCl4 at the same doses as the 3rd and 4th groups. After the experimental duration, measurements of selective indicative parameters of liver function and oxidative stress were performed. It could be concluded that administration of PAs showed a remarkable improvement in the serum levels of hepatic function biomarkers of CCl4--intoxication rats as (AlP, GGT, and LDH), lipid profiles, glucose, albumin, and globulin. Proanthocyanidins also reduced the increase in oxidative stress caused by NO, while rised the activities of hepatic catalase and superoxide dismutase that were reduced by CCl4-intoxication, signifying their antioxidant capacity. Moreover, PAs have an ameliorative effect on haematological parameters (RBCs, WBCs, Hb, platelets). As a result of these findings, PAs administration showed a suppressive role against hepatic fibrosis progression induced by CCl4 in male rats and is recommended for use as a complementary supplement for the treatment of a variety of hepatic diseases

Keywords

Mansoura Journal of Biology
Volume 54, Issue 1
March 2022
Pages 15-27

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