Genetic variations of CYP2D6, CYP3A4 and CYP3A5 in systemic lupus erythematous pediatric patients

Document Type : Original Article

Authors

1 Department of Laboratories, Children Hospital, Faculty of Medicine, Mansoura University, Mansoura, Egypt

2 Department of Pediatrics, Faculty of Medicine, Mansoura University, Mansoura, Egypt

3 The Urology and Nephrology Center, Faculty of Science, Mansoura University, Mansoura, Egypt

4 Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt

Abstract

This study aimed to investigate genetic variations of CYP2D6, CYP3A4 and CYP3A5 in systemic lupus erythematous (SLE) pediatric patients. Methods: CYP2D6*2, *4, *5, *10, *41 and CYP3A4*22 and CYP3A5*3 were determined with commercially available TaqMan assays in 75 SLE patients and 145 healthy study participants. Results: The CYP2D6*2 allele was the most common variant alleles among SLE patients and the healthy participants. No homozygous mutation was detected for CYP3A4*22 in both studied groups. No significant difference in the distribution of allele frequencies was observed between the two groups. Conclusion: The results of this study confirm that there was no difference in the frequency of genetic variations in CYP2D6, CYP3A4 and CYP3A5 between controls and pediatric patients with SLE. Nonetheless, more extensive investigations with a greater number of patients are required to validate and strengthen our findings.

Keywords

Mansoura Journal of Biology
Volume 56, Issue 3
September 2022
Pages 1-5

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