Relation between Psoriasis Severity and P53 Apoptosis Marker in HCV Infection in Mansoura

Document Type : Original Article

Authors

1 Department of Botany, Faculty of Science, Mansoura University, Egypt

2 Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Egypt

3 Dermatology, Andrology & STDs department, Faculty of Medicine, Mansoura University, Egypt

Abstract

Background: It has been planned that hepatitis C virus (HCV) antigens are elaborate in the pathogenesis of psoriasis and may underwrite to the cruelty of the disease. Enlarged levels of the apoptosis-regulating proteins p53 in the keratinocytes of the skin of psoriatic patients have been reported. Objective: study aimed to identify the serum levels of  P53 apoptosis regulating protein in patients with psoriasis with and without HCV infection . Methodology: This case control study was conducted. The present study comprised (28) patients diagnosed with psoriasis one of the differential diagnoses presented to the dermatologic outpatient clinic in Mansoura University Hospital. The cases were collected within a duration of 6 months from May 2019 to October 2019. Results: According. to severity measured by PASI score,5 patients (17.8%) were severe, 6 patients (21.5%) were mild and 17 patient (60.7%) was moderate. there was a highly significant increase P53 in Psoriasis assembly related to the  control group. There was a highly substantial positive correlation between PASI score and P53 level. There was a highly momentous positive connection P53 level and psoriasis affection. There was a statistically significant increase in HCV Ab in the psoriasis group. There was no statistically significant difference between HCV among the degree of severity 

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Mansoura Journal of Biology
Volume 57, Issue 4
December 2022
Pages 1-7

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