Microbiological and Immunological Studies on COVID-19 Patients

Document Type : Original Article

Authors

1 Department of Botany, Faculty of Science, Mansoura University, Mansoura, Egypt.

2 Isolation University Hospital, Faculty of Medicine, Mansoura University.

3 Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Mansoura, Egypt.

Abstract

The coronavirus disease-2019 (COVID-19) epidemic has triggered a worldwide epidemic. Critical breathing pain disease (ARDS) and multiorgan failure are two of the most common reasons of passing in COVID-19-infected disapprovingly sick patients. The increased seditious cytokines propose that a cytokines storm, also known as cytokine release syndromes (CRS), may be complicated in COVID-19 pathogenesis. However, the effectiveness of corticosteroids, which are routinely used anti-inflammatory drugs, in treating COVID-19-induced CRS is debatable. Novel treatments for COVID-19-induced CRS are desperately needed. we describe the pathophysiology of SARS-induced CRS, compare COVID-19 CRS to SARS and Middle East living sickness (MERS), and review current CRS therapeutics. We propose using interleukin-6 (IL-6) inhibition to treat COVID-19-induced CRS.

Keywords

Mansoura Journal of Biology
Volume 58, Issue 5
December 2022
Pages 1-5

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