Therapeutic effect of polyvinylpyrrolidone-capped gold nanorods in dimethylbenzene[a]anthracene induced ovarian cancer in adult femalealbinorat

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Department of Zoology, Faculty of Science,Mansoura University,Mansoura, Egypt

Abstract

The effects of polyvinylpyrrolidone-capped gold nanorods (PVP- capped Au NRs) on ovarian adenocarcinomas in female albino rats induced chemically by 7,12-dimethylbenz[a]anthracene (DMBA) in vivo are investigated in this study. The particles were synthesized by reducing an aqueous solution of gold ions precursor with a chemical reaction. The particles were stabilized against aggregation by PVP. Although the conjugated particles were able to cross the cell membrane and enter the cells via the endocytic route, nothing is known about how PVP- capped Au NRs are transferred. These nanoparticles were described, and 400 µl/rat dosages were given subcutaneously. PVP- capping reduced the amount of gold in various tissues, possibly because of the greater size of capped nanoparticles, which slows the allocation of gold. The ovary underwent histological and immunological examinations. The current findings suggest that PVP-capped Au NRs cross ovarian adenocarcinomas and influence them by inhibiting endothelial cell (EC) viability by binding to vascular endothelial growth factor 165 (VEGF165), a key regulator of endothelial cell function and angiogenesis, and thus decreasing its stimulatory effect, proliferation, and toxicity.

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Mansoura Journal of Biology
Volume 58, Issue 5
December 2022
Pages 26-34

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