Comparison study on the effect of thymoquinone and nano-thymoquinone on lipid profile of diazinon induced toxicity in male rats

Document Type : Original Article

Authors

Physiology Division, Zoology Department, Faculty of Science, Mansoura University, Mansoura, Egypt

10.21608/mjb.2022.459791

Abstract

The objective of the current study was to compaire between the effect of thymoquinone (TQ) and nano-thymoquinone (N-TQ) on lipid profile on diazinon (DZN) induced toxicity in male rats. Rats were haphazardly divided into seven sets, six for each:  Group 1(control): rats receiving distilled water; group 2 (corn oil): rats receiving corn oil by gastric tube daily for 21 days; group 3 (TQ): rats receiving TQ (40 mg / kg bw) daily oral administration for 21days; group 4(N-TQ): rats receiving N-TQ (40mg/kg bw) oral administration for 21 days ;group 5 (DZN):  Rats are given DZN (15 mg/kg bw) orally for 21 days; group 6 (TQ +DZN) rats of this group orally received TQ then after one hour DZN for 21 days and group 7 (N-TQ +DZN) rats of this group orally received N-TQ then after one hour DZN for 21 days. Our results showed significant increases TC, TG, LDL-C, as well as major decreases in HDL-C in serum. On the other hand, TQ and N-TQ administration significantly improved the deviation resulting from DZN in the tested parameters. Ultimately, it could be concluded that to boost the hepatic damage caused by DZN, TQ and N-TQ should be taken before DZN. Although, the effect of N-TQ was more effective.

Keywords

Mansoura Journal of Biology
Volume 60, Issue 7
December 2022
Pages 46-53

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