Antibacterial Activity of Syzygium aromaticum (Clove) Against MDR ‎Bacteria Isolated from Diabetic Foot Ulcer and Wound healing

Document Type : Original Article

Authors

1 Department of Botany and Microbiology, Faculty of Science, Mansoura University, ‎Mansoura, Egypt

2 Department of Botany and Microbiology, Faculty of Science, Zagazig University, ‎Zagazig, Egypt.‎

10.21608/mjb.2021.460006

Abstract

Diabetes mellitus is a chronic lifelong disorder that distinguishes oneself by chronic ‎hyperglycemia and caused damage to organs. Bad control of diabetes leads to skin ‎infections and non-healing foot ulcers which are common in clinical practice. The access ‎to the hospital and mutilation will increase and conversely result in long-term ‎economic, physical, social, and mental disability to the patient. This study is designed ‎to isolate and determine the susceptibility of isolated bacteria to different antibiotics. ‎Drug-resistant bacteria were selected and identified by vitek system 2 and MIC of ‎these isolates were determined. Results revealed that 83 isolates were isolated from ‎‎47 patients with diabetic foot infection polymicrobial growth cultures were found in ‎all-patients. Gram negative bacteria showed a high percentage of resistance to tested ‎antibiotics. Proteus mirabilis isolate LC587231 record the highest index of ‎antibiotics resistance (0.83). This isolate inhibited by ethanolic extracts of clove at ‎MIC = 12.89 ug/ml and topical application of hydrogel containing clove extract ‎improved wound size, wound index of infected diabetic wound model‎.

Keywords

Mansoura Journal of Biology
Volume 53, Issue 4
December 2021
Pages 42-54

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