Coenzyme Q10 prevents Oxidative Stress and Cardiac Disorders in ISO- treated Male Rats

Document Type : Original Article

Authors

1 Animal Physiology and Ecology Zoology Department, Faculty of Science, Mansoura University, 35516, Egypt

2 Master candidate, Animal Physiology and Ecology Zoology Department, Faculty of Science, Mansoura University

10.21608/mjb.2021.460094

Abstract

The affliction of heart-ailment and metabolic diseases is amassed every single year. heart-ailment are an energy-depleted state allied with little myocardial-adenosine-triphosphate (A.T.P) production, mitochondria dysfunction, Oxidative stress, augmented reactive oxygen species generation, and endothelial dysfunction. There is a prerequisite for innovative approaches to prophylaxis and treatment. Coenzyme-Q.10 (Co.Q10) is a crucial compound for the body. There is upward substantiation that Co.Q10 is compactly allied to cardiac disorders. It can be baptized as the strategic constituent of the electron transport chain in mitochondria necessary for ATP production. As well, it dramas a key-part in protons 'transfer in the inner mitochondrial membrane. Consequently, this study targets to appraise the role of CoQ10 vs myocardial infarct in male rats. Rats were categorized into four groups vs. Control group, Q10 treated group, ISO treated group, and CoQ10 + ISO treated group, each comprising of 6 rats. Lipid profile, biochemical functions of heart and liver, oxidative stress markers, and anti-oxidative stress indicators were scrutinized. Administration of ISO occasioned an increase in total lipid profile. Serum levels of biochemical tests bared significant results, and oxidative stress markers showed a significant increase in ISO-treated rats. Treatment with CoQ10 expressively value-added the oxidative stresses in ISO-treated rats. In conclusion, it was pragmatic that administering the CoQ10 exhibited deterrent results contrary to myocardial infarct instigated by injection with isoproterenol (ISO) 

Keywords

Mansoura Journal of Biology
Volume 51, Issue 2
June 2021
Pages 20-27

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