Role of radish root extract in modulating doxorubicin- induced cardiotoxicity in male rats

Document Type : Research Article

Authors

Zoology Department, Faculty of Science, Mansoura University, Egypt

10.21608/mjb.2020.460683

Abstract

This study aimed to evaluate the role of radish root extract (RRE) in modulating doxorubicin (DOX)- induced cardiotoxicity in male rats. DOX was injected intraperitoneally in 8 equal doses (each containing 2.5mg/kg BW) twice weekly for 4 weeks, whereas RRE (30mg/kg BW) was given orally, 6 days/week for the same duration. DOX-treated rats elicited marked increase in serum levels of cardiac troponin-I and enzymes; creatine kinase-MB, lactate dehydrogenase  and aspartate aminotransferase, with significant decrease in the body weight (BW), heart weight (HW) and heart /body weight ratio. Results also showed increased  cardiac xanthine oxidase , malondialdehyde,  protein carbonyl  and nitric oxide ,  with decreased antioxidants; reduced glutathione , superoxide dismutase and catalase, as well as total antioxidant capacity. Increased serum inflammatory markers (tumor necrosis factor α and C-reactive protein), and adhesion molecules (intercellular adhesion molecule-1 and vascular cell adhesion molecule-1) were also recorded. Besides, a decrease in RBCs count, Hb content, Ht%, MCV, MCH and platelets count with increased leucocytes count were observed. Supplementation of RRE tended to protect against DOX-induced cardiotoxicity, as evidenced via normalizing heart weight, cardiac biomarkers, oxidative stress and inflammatory response. Thus, recommendation for regarding consumption of RRE during DOX treatment should be made.

Keywords

Mansoura Journal of Biology
Volume 48, Issue 3
September 2020
Pages 1-12

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