Herbal antibiofilm effects against phenotypically and genotypically detected clinical Methicillin-resistant staphylococcus aureus isolates

Document Type : Original Article

Authors

1 Department of Botany, Faculty of Science, Mansoura University, Egypt

2 Department of Medical Microbiology and Immunology, Faculty of Medicine, Mansoura University, Egypt.

10.21608/mjb.2022.459788

Abstract

This study was conducted to detect the effect of some medicinal plant extracts on the biofilm formation of Methicillin-resistant staphylococcus aureus (MRSA) isolated from patients in Mansoura University Hospitals.
Results: Fifty samples (Blood, Wound swab, nasal swab and urine) from patients revealed the total number of isolates were methicillin-resistant staphylococcus aureus (MRSA). Molecular analysis revealed that mec Agene was detected in all isolates. then MRSA isolates were positive for biofilm genes specific (icaA and icaD). Among all herbal plant extracts, Camellia sinensis (green tea) extract was the greater inhibitor of  the biofilm formation of MRSA isolates. In this connection, this effect showed the lysis of MRSA cell wall through Transmission Electron Microscope (TEM).
Conclusions: Camellia sinensis leaf extracts could be valuable in fighting evolving drug- resistance caused by MRSA.

Keywords

Mansoura Journal of Biology
Volume 60, Issue 7
December 2022
Pages 19-26

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